Semaglutide

The GLP-1 Single Agonist Peptide is a potent, long-acting synthetic peptide designed to selectively activate the glucagon-like peptide-1 receptor (GLP-1R). It mimics the action of endogenous GLP-1, a hormone involved in glucose metabolism and appetite regulation. This peptide is primarily utilized in research settings to study metabolic control mechanisms.

Pharmacokinetics and mechanism highlights include:

• Selective binding and activation of GLP-1 receptors located in the pancreas, gastrointestinal tract, and brain, promoting glucose-dependent insulin secretion and inhibiting glucagon release when blood glucose levels are elevated.
• Slowing of gastric emptying, which aids in postprandial glucose control and enhances satiety, thereby reducing appetite and assisting weight management.
• The peptide shares approximately 94% structural homology with human GLP-1 but includes structural modifications such as fatty acid acylation that confer strong plasma albumin binding, protecting it from enzymatic degradation and extending its half-life.
• The terminal elimination half-life ranges from approximately 145 to 168 hours (6 to 7 days), allowing for convenient once-weekly subcutaneous dosing in clinical contexts.
• Metabolized by general protein degradation pathways without involvement of cytochrome P450 enzymes, minimizing potential for drug-drug interactions.
• Recognized for sustained glycemic control, body weight reduction, and improved cardiovascular risk factors in clinical studies.

The GLP-1 Single Agonist Peptide is provided exclusively for laboratory research purposes and molecular studies. It is not intended for diagnostic, therapeutic, or clinical use and must not be administered to humans or animals. For Research Use Only.

Product details:

• Molecular Weight: Approximately 4113 Da
• Molecular Formula: C187H291N45O59
• Appearance: White to off-white lyophilized powder or solution for injection
• Approved formulations: Subcutaneous injectable solution for diabetes and weight management

This product is intended exclusively for scientific research and laboratory investigation in compliance with applicable regulatory guidelines.