Snap-8 10 MG

SNAP-8 is a synthetic octapeptide (acetylated glutamyl heptapeptide-1) designed as a topical neuromodulator with anti-wrinkle and skin-smoothing properties. It is structurally derived from the SNARE protein complex component SNAP-25, which is critical in neurotransmitter release for muscle contraction.

Mechanism of action and pharmacological insights of SNAP-8:

• SNAP-8 mimics the N-terminal end of SNAP-25 and competitively disrupts the formation of the SNARE complex (composed of SNAP-25, syntaxin, and synaptobrevin), which is essential for synaptic vesicle fusion and neurotransmitter release.
• By interfering with SNARE complex assembly, SNAP-8 reduces acetylcholine release at neuromuscular junctions, leading to decreased muscle contraction, particularly in facial muscles responsible for expression lines and wrinkles.
• This effect is similar to botulinum toxin (Botox) but works via a non-invasive topical route and a milder mechanism.
• Additionally, SNAP-8 may influence contractile fibroblast activity in the dermis, reducing micro-tensions within the skin, which contributes to decreased wrinkle depth and improved skin texture.
• The peptide sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 includes N-terminal acetylation for enhanced stability and enzymatic resistance, improving its efficacy in topical formulations.
• Clinical and in vitro studies indicate that SNAP-8 can reduce wrinkle depth by around 30–60% with regular application, complementing other peptides like Argireline for anti-aging effects.

Product details:

• Amino Acid Sequence: Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
• Molecular Weight: Approximately 888 Da
• Appearance: White to off-white lyophilized powder or topical formulation
• Use: Primarily in cosmetic topical products for wrinkle reduction

SNAP-8 represents a non-invasive, safer alternative to injectable neuromodulators, targeting facial muscle activity and improving skin topography by modulating acetylcholine neurotransmission and dermal contractile cells.